منابع مشابه
MiR-29/Hsp47 in ECM network
Cancer development and progression require extensive reorganization of extracellular matrix [1, 2]. ECM is a complex mixture of structural proteins, glycoproteins, and proteoglycans, which provide not only essential physical scaffolds to maintain tissues structure but also various biochemical signals to modulate cellular function. Altering the fine balance of ECM signal is sufficient in the lon...
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اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...
15 صفحه اولECM signals ECM degradation
W hen Caroline Damsky moved her lab to the University of California, San Francisco, in 1985, she knew she would have an instant colleague in Zena Werb. There was a natural connection between their work. That connection would be refl ected in their discoveries, which delineated an integrin-mediated pathway from the extracellular matrix (ECM) outside the cell to the internal, gene-expressing life...
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Tumor angiogenesis promotes tumor growth and metastasis. Here, we use automated sequential microprinting of tumor and endothelial cells in extracellular matrix (ECM) scaffolds to study its mechanical aspects. Quantitative reflection microscopy shows that tumor spheroids induce radial orientation of the surrounding collagen fiber network up to a distance of five times their radius. Across a pane...
متن کاملDrosophila miR-9a targets the ECM receptor Dystroglycan to canalize myotendinous junction formation.
Establishment of intercellular interactions between various cell types of different origin is vital for organism development and tissue maintenance. Therefore, precise timing, expression pattern, and amounts of extracellular matrix (ECM) proteins must be tightly regulated. Particularly, the ECM is important for the development and function of myotendinous junctions (MTJs). We find that precise ...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.227